Hembase : NIDDK
Skip Flash Object This animation illustrates human erythropoiesis whereby stem cells or hematopoietic stem cells differenciate into red cells
Based on the mapping of the human genome and the development of information databases, a broad description of genes transcribed in blood cells is now known. Hembase was developed to provide worldwide access to those genetic-based studies performed by scientists in the Molecular Biology and Genetics Section, Molecular Medicine Branch, Division of Intramural Research, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This project represents the shared goal of several individuals and groups (credits) interested in disseminating genomic information on the World Wide Web.
Hembase Focus: Red Cells
The production of red blood cells occurs by a process called erythropoiesis whereby erythroid progenitor cells proliferate and differentiate into erythroid precursor cells (see figure above). Normally, this process is highly dependent upon and regulated by a hormone produced by the kidneys called erythropoietin. Our laboratory investigates genes transcribed in human erythroid cells as they differentiate into mature red blood cells. Red blood cells have the fundamental role of delivering oxygen from the lungs to the other body tissues, and diseases associated with erythroid cells affect millions of people. We hope this data will be useful for the understanding and improved treatment or prevention of those diseases including all forms of anemia, erythroleukemia, and malaria.
Hembase Content
Red blood cells in the circulation arise from hematopoietic stem cells that proliferate as erythroid progenitors and differentiate into erythroid precursor cells in response to the hormone erythropoietin. Messenger RNA was isolated from those cells and used to generate gene libraries. Sequencing several thousand expressed sequence tags (EST) from those libraries was then performed. Those EST and sequences encoding several hundred additional genes with known expression in erythroid cells are compiled here as a database of human erythroid gene activity. The database is organized and linked according to the location of these sequences within the human genome.
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For questions, contact Jeffery L. Miller

National Institute of Diabetes and Digestive and Kidney Diseases NIDDK) is part of the National Institutes of Health, Bethesda, MD, USA.

National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of HealthDepartment of Health and Human Services